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1

Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function

Grover, Prerna, Shi, Haibin, Baumgartner, Matthew, Camacho, Carlos J., Smithgall, Thomas E., Buday, Laszlo

Journal:

Year:

2015

Language:

english

File:

PDF, 5.24 MB

english, 2015

2

Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer

Jonathan M. Shaffer, Thomas E. Smithgall

Journal:

Genes, Chromosomes and Cancer

Year:

2009

Language:

english

File:

PDF, 1014 KB

english, 2009

3

Separation of NOEs from Degenerate Amide Protons in13C/15N-Labeled Proteins Using a 3D13C′-Edited NOESY-H(N)CO Experiment

Weixing Zhang, Thomas E. Smithgall, William H. Gmeiner

Journal:

Journal of Magnetic Resonance, Series B

Year:

1996

Language:

english

File:

PDF, 157 KB

english, 1996

4

Use of ProteinChip™ array surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) to identify thymosinβ-4, a differentially secreted protein from lymphoblastoid cell lines

Deborah L Diamond, Yanni Zhang, Alexander Gaiger, Molly Smithgall, Thomas S Vedvick, Darrick Carter

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2003

Language:

english

File:

PDF, 146 KB

english, 2003

5

Stimulation of the phosphorylation of uridine in skeletal muscle by insulin and vanadate

Niels Haugaard, Aliza Torbati, Thomas Smithgall, Gary Wildey

Journal:

Molecular and Cellular Biochemistry

Year:

1990

Language:

english

File:

PDF, 509 KB

english, 1990

6

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

Molina, Gabriela, Vogt, Andreas, Bakan, Ahmet, Dai, Weixiang, de Oliveira, Pierre Queiroz, Znosko, Wade, Smithgall, Thomas E, Bahar, Ivet, Lazo, John S, Day, Billy W

Journal:

Nature Chemical Biology

Year:

2009

Language:

english

File:

PDF, 1.21 MB

english, 2009

7

SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo

Lerner, Edwina C., Smithgall, Thomas E.

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 1.27 MB

english, 2002

8

Control of myeloid differentiation and survival by Stats

Smithgall, Thomas E, Briggs, Scott D, Schreiner, Steven, Lerner, Edwina C, Cheng, Haiyun, Wilson, Matthew B

Journal:

Year:

2000

Language:

english

File:

PDF, 133 KB

english, 2000

9

Involvement of Jak2 tyrosine phosphorylation in Bcr–Abl transformation

Xie, Shanhai, Wang, Yan, Liu, Jiaxin, Sun, Tong, Wilson, Matthew B, Smithgall, Thomas E, Arlinghaus, Ralph B

Journal:

Year:

2001

Language:

english

File:

PDF, 262 KB

english, 2001

10

Differential function of STAT5 isoforms in head and neck cancer growth control

Leong, Paul L, Xi, Sichuan, Drenning, Stephanie D, Dyer, Kevin F, Wentzel, Abbey L, Lerner, Edwina C, Smithgall, Thomas E, Grandis, Jennifer Rubin

Journal:

Year:

2002

Language:

english

File:

PDF, 274 KB

english, 2002

11

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr–Abl signal transduction and oncogenesis

Wilson, Matthew B, Schreiner, Steven J, Choi, Hyun-Jung, Kamens, Joanne, Smithgall, Thomas E

Journal:

Year:

2002

Language:

english

File:

PDF, 342 KB

english, 2002

12

Arsenic inhibition of the JAK-STAT pathway

Cheng, Haiyun Y, Li, Ping, David, Michael, Smithgall, Thomas E, Feng, Lili, Lieberman, Michael W

Journal:

Year:

2004

Language:

english

File:

PDF, 398 KB

english, 2004

13

Three-dimensional structure of the Hck SH2 domain in solution

Weixing Zhang, Thomas E. Smithgall, William H. Gmeiner

Journal:

Journal of Biomolecular NMR

Year:

1997

Language:

english

File:

PDF, 697 KB

english, 1997

14

Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck: PPIIhGAP

William H. Gmeiner, Jianzhao Xu, David A. Horita, Thomas E. Smithgall, John R. Engen, David L. Smith, R. Andrew Byrd

Journal:

Cell Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 173 KB

english, 2001

15

The role of neuroD as a differentiation factor in the mammalian retina

Iqbal Ahmad, Harsha R. Acharya, Jim A. Rogers, Annemarie Shibata, Thomas E. Smithgall, Constance M. Dooley

Journal:

Journal of Molecular Neuroscience

Year:

1998

Language:

english

File:

PDF, 286 KB

english, 1998

16

An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry

James M. Hochrein, Edwina C. Lerner, Anthony P. Schiavone, Thomas E. Smithgall, John R. Engen

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 442 KB

english, 2006

17

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding

Shugui Chen, Sébastien Brier, Thomas E. Smithgall, John R. Engen

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 900 KB

english, 2007

18

Dynamics of the Hck-SH3 domain: Comparison of experiment with multiple molecular dynamics simulations

David A. Horita, R. Andrew Byrd, Weixing Zhang, Thomas E. Smithgall, William H. Gmeiner

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 990 KB

english, 2000

19

SH2 and SH3 domains: Potential targets for anti-cancer drug design

Thomas E. Smithgall

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

1995

Language:

english

File:

PDF, 990 KB

english, 1995

20

Fibroblast growth factor-2 induces the activation of Src through Fes, which regulates focal adhesion disassembly

Shigeru Kanda, Yasuyoshi Miyata, Hiroshi Kanetake, Thomas E. Smithgall

Journal:

Experimental Cell Research

Year:

2006

Language:

english

File:

PDF, 760 KB

english, 2006

21

The c-Fes protein-tyrosine kinase accelerates NGF-induced differentiation of PC12 cells through a PI3K-dependent mechanism

Annemarie Shibata, Charles E Laurent, Thomas E Smithgall

Journal:

Cellular Signalling

Year:

2003

Language:

english

File:

PDF, 669 KB

english, 2003

22

Tyrosine Phosphorylation Enhances the SH2 Domain-Binding Activity of Bcr and Inhibits Bcr Interaction with 14-3-3 Proteins

Kristi L Peters, Thomas E Smithgall

Journal:

Cellular Signalling

Year:

1999

Language:

english

File:

PDF, 529 KB

english, 1999

23

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

Teodora Pene-Dumitrescu, Sherry T Shu, Thomas E Wales, John J Alvarado, Haibin Shi, Purushottam Narute, Jamie A Moroco, Joanne I Yeh, John R Engen, Thomas E Smithgall

Journal:

BMC Chemical Biology

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

24

Solution structure of the human Hck SH3 domain and identification of its ligand binding site

David A. Horita, Donna M. Baldisseri, Weixing Zhang, Amanda S. Altieri, Thomas E. Smithgall, William H. Gmeiner, R.Andrew Byrd

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 873 KB

english, 1998

25

Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3 + 2) construct: the role of protein dynamics in functional regulation

John R Engen, Thomas E Smithgall, William H Gmeiner, David L Smith

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 375 KB

english, 1999

26

Indomethacin-sensitive 3α-hydroxysteroid dehydrogenase in rat tissues

Thomas E. Smithgall, Trevor M. Penning

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 402 KB

english, 1985

27

Chromosomal protein HMG-14 is overexpressed in Down syndrome

James Pash, Thomas Smithgall, Michael Bustin

Journal:

Experimental Cell Research

Year:

1991

Language:

english

File:

PDF, 400 KB

english, 1991

28

Conserved Residues in the HIV-1 Nef Hydrophobic Pocket are Essential for Recruitment and Activation of the Hck Tyrosine Kinase

Hyun-Jung Choi, Thomas E. Smithgall

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 694 KB

english, 2004

29

Functional Characterization and Conformational Analysis of the Herpesvirus saimiri Tip-C484 Protein

Jennifer L. Mitchell, Ronald P. Trible, Lori A. Emert-Sedlak, David D. Weis, Edwina C. Lerner, Jeremy J. Applen, Bartholomew M. Sefton, Thomas E. Smithgall, John R. Engen

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 700 KB

english, 2007

30

Allosteric Loss-of-function Mutations in HIV-1 Nef from a Long-term Non-progressor

Ronald P. Trible, Lori Emert-Sedlak, Thomas E. Wales, Velpandi Ayyavoo, John R. Engen, Thomas E. Smithgall

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 637 KB

english, 2007

31

Tyrosine Phosphorylation in the SH3 Domain Disrupts Negative Regulatory Interactions within the c-Abl Kinase Core

Shugui Chen, Linda P. O'Reilly, Thomas E. Smithgall, John R. Engen

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 919 KB

english, 2008

32

HIV-1 Nef Dimerization Is Required for Nef-Mediated Receptor Downregulation and Viral Replication

Jerrod A. Poe, Thomas E. Smithgall

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 747 KB

english, 2009

33

On the Solution Conformation and Dynamics of the HIV-1 Viral Infectivity Factor

Sean R. Marcsisin, Purushottam S. Narute, Lori A. Emert-Sedlak, Marek Kloczewiak, Thomas E. Smithgall, John R. Engen

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 2.19 MB

english, 2011

34

Utilizing a small molecule screen to delineate kidney development

Neil A. Hukriede, Eric D. De Groh, Rachel Jackson, Weixiang Dai, Billy W. Day, Thomas E. Smithgall

Journal:

Developmental Biology

Year:

2008

Language:

english

File:

PDF, 76 KB

english, 2008

35

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner

Charles E Laurent, Thomas E Smithgall

Journal:

Experimental Cell Research

Year:

2004

Language:

english

File:

PDF, 675 KB

english, 2004

36

Lyn regulates the cell death response to ultraviolet radiation through c-Jun N terminal Kinase-dependent Fas ligand activation

Sanjeev Shangary, Edwina C Lerner, Qimin Zhan, Seth J Corey, Thomas E Smithgall, R Baskaran

Journal:

Experimental Cell Research

Year:

2003

Language:

english

File:

PDF, 505 KB

english, 2003

37

Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase

Weixing Zhang, Thomas E. Smithgall, William H. Gmeiner

Journal:

Year:

1997

Language:

english

File:

PDF, 619 KB

english, 1997

38

Rat liver 3α-hydroxysteroid dehydrogenase

Trevor M Penning, Thomas E Smithgall, Leslie J Askonas, Robert B Sharp

Journal:

Year:

1986

Language:

english

File:

PDF, 3.62 MB

english, 1986

39

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

Perrone, Rosalba, Nadai, Matteo, Frasson, Ilaria, Poe, Jerrod A., Butovskaya, Elena, Smithgall, Thomas E., Palumbo, Manlio, Palù, Giorgio, Richter, Sara N.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.16 MB

english, 2013

40

Small molecule inhibitors of the HIV-1 virulence factor, Nef

Smithgall, Thomas E., Thomas, Gary

Journal:

Drug Discovery Today: Technologies

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

41

Synthesis and structure–activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor

Iyer, Prema C., Zhao, Jielu, Emert-Sedlak, Lori A., Moore, Kerry K., Smithgall, Thomas E., Day, Billy W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 770 KB

english, 2014

42

First International Congress of Plan Molecular Biology

O'Reilly, Linda P., Zhang, Xiong, Smithgall, Thomas E.

Journal:

Year:

1984

Language:

english

File:

PDF, 113 KB

english, 1984

43

Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation

O'Reilly, Linda P., Zhang, Xiong, Smithgall, Thomas E.

Journal:

Cellular Signalling

Year:

2013

Language:

english

File:

PDF, 760 KB

english, 2013

44

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

Emert-Sedlak, Lori A., Narute, Purushottam, Shu, Sherry T., Poe, Jerrod A., Shi, Haibin, Yanamala, Naveena, Alvarado, John Jeff, Lazo, John S., Yeh, Joanne I., Johnston, Paul A., Smithgall, Thomas E.

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

45

Phosphorylation-Dependent Human Immunodeficiency Virus Type 1 Infection and Nuclear Targeting of Viral DNA

Alice G. Bukrinskaya, Anuja Ghorpade, Nina K. Heinzinger, Thomas E. Smithgall, Robert E. Lewis and Mario Stevenson

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 621 KB

english, 1996

46

Chemical Library Screens Targeting an HIV-1 Accessory Factor/Host Cell Kinase Complex Identify Novel Antiretroviral Compounds

Emert-Sedlak, Lori, Kodama, Toshiaki, Lerner, Edwina C., Dai, Weixiang, Foster, Caleb, Day, Billy W., Lazo, John S., Smithgall, Thomas E.

Journal:

ACS Chemical Biology

Year:

2009

Language:

english

File:

PDF, 755 KB

english, 2009

47

Affinity of Src Family Kinase SH3 Domains for HIV Nef in Vitro Does Not Predict Kinase Activation by Nef in Vivo †

Briggs, Scott D., Lerner, Edwina C., Smithgall, Thomas E.

Journal:

Year:

2000

Language:

english

File:

PDF, 128 KB

english, 2000

48

Self-Association and Backbone Dynamics of the Hck SH2 Domain in the Free and Phosphopeptide-Complexed Forms †

Zhang, Weixing, Smithgall, Thomas E., Gmeiner, William H.

Journal:

Year:

1998

Language:

english

File:

PDF, 159 KB

english, 1998

49

Bimolecular Fluorescence Complementation Demonstrates That the c-Fes Protein−Tyrosine Kinase Forms Constitutive Oligomers in Living Cells

Shaffer, Jonathan M., Hellwig, Sabine, Smithgall, Thomas E.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.79 MB

english, 2009

50

Abl N-Terminal Cap Stabilization of SH3 Domain Dynamics †

Chen, Shugui, Dumitrescu, Teodora Pene, Smithgall, Thomas E., Engen, John R.

Journal:

Year:

2008

Language:

english

File:

PDF, 801 KB

english, 2008